Tracer studies on the distribution and excretion of uranium in mice, rats, and dogs
The excretion of uranium and distribution of uranium in tissues following injection of uranyl nitrate was studied in mice, rats, and dogs. Highly radioactive isotopes of uranium were used either as tracers or alone; radioautographs as well as analytical data were obtained. The conclusions of the studies are summarized as follows: (1) a high proportion of the uranium is excreted in the urine within 24 hours after injection. Much smaller proportions are excreted during this period when the dosages are toxic than when they are non-toxic; (2) initially fecal excretion of uranium is relatively low, but as the urinary excretion rapidly decreases, the fecal uranium may assume significant proportions; (3) less than 10% of the injected uranium remains in the body by one month following injection of non-toxic dosages of uranyl nitrate. When the injected dose is toxic as much as 40% may be retained; (4) the kidneys and bones are the principal sites of accumulation (retention) of the injected uranium; (5) radio-autographs indicate that in bone, uranium accumulates almost entirely in the cancellous portion (trabeculae) and endosteum; (6) similar radio-autographic studies on kidney reveal that the cortex is the essential site of accumulation with some tendency for concentration at the cortico-medullary junction.
- Research Organization:
- Michael Reese Hospital, Chicago, IL (USA)
- OSTI ID:
- 6179909
- Report Number(s):
- CH-3659-C; ON: DE85003487
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ANIMALS
CLEARANCE
DATA
DISTRIBUTION
DOGS
EXCRETION
EXPERIMENTAL DATA
INFORMATION
INJECTION
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MICE
NITRATES
NITROGEN COMPOUNDS
NUMERICAL DATA
OXYGEN COMPOUNDS
RATS
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
URANIUM COMPOUNDS
URANIUM ISOTOPES
URANYL COMPOUNDS
URANYL NITRATES
VERTEBRATES