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Kinetics of the inhibition and recovery of semiconservative DNA synthesis following the induction of non-dimer DNA damages by solar ultraviolet radiation in ICR 2A frog cells

Journal Article · · Environ. Mutagen.; (United States)
The purpose of the work presented in this paper was to investigate the kinetics of inhibition and recovery of DNA synthesis in cells following the solar UV induction of non-dimer DNA damages. This work was accomplished by exposing cells to the Mylar-filtered solar UV wavelengths produced by fluorescent sunlamps. The ICR 2A frog cell line was chosen for this study because it is highly proficient in enzymatic photoreactivation. Hence, it was possible to induce a relatively pure population of non-dimer DNA photoproducts by exposing the sunlamp-irradiated cells to photoreactivating light (PRL), which specifically eliminates most of the small yield of dimers induced by the solar UV irradiation.
Research Organization:
Univ. of Texas Health Science Center, Dallas
OSTI ID:
6179133
Journal Information:
Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 7:6; ISSN ENMUD
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMPHIBIANS
ANIMAL CELLS
ANIMALS
AQUATIC ORGANISMS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARBON 14 COMPOUNDS
COBALT 60
COBALT ISOTOPES
DNA REPLICATION
ELECTROMAGNETIC RADIATION
EXTREME ULTRAVIOLET RADIATION
FAR ULTRAVIOLET RADIATION
FROGS
GAMMA RADIATION
INHIBITION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
MINUTES LIVING RADIOISOTOPES
NEAR ULTRAVIOLET RADIATION
NUCLEI
NUCLEIC ACID REPLICATION
ODD-ODD NUCLEI
PHOTOREACTIVATION
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RECOVERY
REPAIR
SOLAR RADIATION
STELLAR RADIATION
TRITIUM COMPOUNDS
ULTRAVIOLET RADIATION
VERTEBRATES
YEARS LIVING RADIOISOTOPES