Reversal of 2-deoxyglucose uptake pattern across rat superior colliculus layers during recovery from visual cortex ablation

Journal Article · Sat Aug 01 04:00:00 EDT 1987 · Exp. Neurol.; (United States)

DOI:https://doi.org/10.1016/0014-4886(87)90103-8· OSTI ID:6178866

Glimpel, P B; Thurlow, G A; Cooper, R M

The 2-deoxy-D-(/sup 14/C)glucose autoradiographic technique was used to assess metabolic activity across stratum griseum superficiale, stratum opticum, and stratum griseum mediale of the superior colliculus, at intervals of 1 to 90 days after a unilateral visual cortex lesion. Initially, glucose metabolism ipsilateral to the lesion was more depressed in stratum griseum mediale than in superficiale, but beginning at about 14 days postlesion this layer pattern reversed. The rise in mediale metabolic activity correlated in time with a decline in generalized cortical depression. On the basis of anatomic connections, we concluded that the generalized cortical depression had disrupted input to stratum griseum mediale from cortical areas other than area 17, and that with recovery of cortical metabolic activity, stratum griseum mediale metabolic activity increased to nearly normal.

• Research Organization: Univ. of Calgary, Alberta
• OSTI ID: 6178866
• Journal Information: Exp. Neurol.; (United States), Journal Name: Exp. Neurol.; (United States) Vol. 97:2; ISSN EXNEA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
AUTORADIOGRAPHY
BODY
BRAIN
CARBOHYDRATES
CARBON 14 COMPOUNDS
CENTRAL NERVOUS SYSTEM
GLUCOSE
HEXOSES
LABELLED COMPOUNDS
MAMMALS
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
RATS
RODENTS
SACCHARIDES
VERTEBRATES