Effect of hyperbaric oxygen on glucose utilization in a freeze-traumatized rat brain

Journal Article · Fri Jan 01 04:00:00 EST 1988 · J. Neurosurg.; (United States)

DOI:https://doi.org/10.3171/jns.1988.68.1.0137· OSTI ID:5513826

Contreras, F L; Kadekaro, M; Eisenberg, H M

Local cerebral glucose utilization was measured with the autoradiographic 2-deoxyglucose technique in rats injured by a focal parietal cortical freeze lesion then treated with hyperbaric oxygen (HBO). The cold lesion depressed glucose utilization in the contralateral as well as in the ipsilateral hemisphere. The largest decreases were observed in ipsilateral cortical areas. Treatment of lesioned animals with HBO at 2 atm for 90 minutes on each of 4 consecutive days tended to increase the overall cerebral glucose utilization measured 5 days after injury when compared to animals exposed to normobaric air. This improvement reached statistical significance in five of the 21 structures studied: the auditory cortex, medial geniculate body, superior olivary nucleus, and lateral geniculate body ipsilateral to the lesion, and the mammillary body. The data indicate that changes in lesioned rats exposed to HBO are not restricted to the period of time that the animals are in the hyperbaric chamber but are persistent.

• Research Organization: Univ. of Texas Medical Branch, Galveston
• OSTI ID: 5513826
• Journal Information: J. Neurosurg.; (United States), Journal Name: J. Neurosurg.; (United States) Vol. 68:1; ISSN JONSA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
AUTORADIOGRAPHY
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
ELEMENTS
FREEZING
GLUCOSE
HEXOSES
MAMMALS
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
NONMETALS
ORGANIC COMPOUNDS
ORGANS
OXYGEN
RATS
RODENTS
SACCHARIDES
VERTEBRATES