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The role of constitutive and inducible processes in the response of human squamous cell carcinoma cell lines to ionizing radiation

Conference ·
OSTI ID:6177262
The inherent radiation sensitivity of the cells within a tumor is thought to contribute to the success or failure of radiation therapy. In vitro studies have shown that radiation sensitivity differences in squamous cell carcinoma cell lines reflect alterations in DNA repair. These alterations result from constitutive changes in chromosome organization, not radiation-inducible processes. While inducible responses may play some role in the radiation response of tumor cells, there is no evidence for their involvement in inherent tumor cell radiosensitivity differences or in the success or failure of radiotherapy for squamous cell carcinomas.
Research Organization:
Argonne National Lab., IL (United States)
Sponsoring Organization:
DOE; USDOE, Washington, DC (United States)
DOE Contract Number:
W-31109-ENG-38
OSTI ID:
6177262
Report Number(s):
ANL/BIM/CP-79672; CONF-9305202--2; ON: DE93015150
Country of Publication:
United States
Language:
English

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Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
560151 -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL CYCLE
CELL TRANSFORMATIONS
DNA REPAIR
ELECTROMAGNETIC RADIATION
ENZYME INDUCTION
GENE REGULATION
IONIZING RADIATIONS
MAMMALS
MAN
MEDICINE
NUCLEAR MEDICINE
ONCOGENIC TRANSFORMATIONS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
REPAIR
SOMATIC CELLS
SURVIVAL CURVES
THERAPY
VERTEBRATES
X RADIATION