The role of constitutive and inducible processes in the response of human squamous cell carcinoma cell lines to ionizing radiation
Conference
·
OSTI ID:10162070
The inherent radiation sensitivity of the cells within a tumor is thought to contribute to the success or failure of radiation therapy. In vitro studies have shown that radiation sensitivity differences in squamous cell carcinoma cell lines reflect alterations in DNA repair. These alterations result from constitutive changes in chromosome organization, not radiation-inducible processes. While inducible responses may play some role in the radiation response of tumor cells, there is no evidence for their involvement in inherent tumor cell radiosensitivity differences or in the success or failure of radiotherapy for squamous cell carcinomas.
- Research Organization:
- Argonne National Lab., IL (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 10162070
- Report Number(s):
- ANL/BIM/CP--79672; CONF-9305202--2; ON: DE93015150
- Country of Publication:
- United States
- Language:
- English
Similar Records
The role of constitutive and inducible processes in the response of human squamous cell carcinoma cell lines to ionizing radiation
The role of constitutive and inducible processes in the response of human squamous cell carcinoma cell lines to ionizing radiation
Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients
Conference
·
Thu Dec 31 23:00:00 EST 1992
·
OSTI ID:6177262
The role of constitutive and inducible processes in the response of human squamous cell carcinoma cell lines to ionizing radiation
Journal Article
·
Thu Mar 31 23:00:00 EST 1994
· Radiation Research
·
OSTI ID:56763
Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients
Journal Article
·
Mon Mar 31 23:00:00 EST 1986
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:5651176
Related Subjects
560120
560151
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL RADIATION EFFECTS
CELL CYCLE
DNA REPAIR
ENZYME INDUCTION
MAN
ONCOGENIC TRANSFORMATIONS
RADIATION EFFECTS ON BIOCHEMICALS, CELLS, AND TISSUE CULTURE
RADIOTHERAPY
SOMATIC CELLS
SURVIVAL CURVES
X RADIATION
560151
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL RADIATION EFFECTS
CELL CYCLE
DNA REPAIR
ENZYME INDUCTION
MAN
ONCOGENIC TRANSFORMATIONS
RADIATION EFFECTS ON BIOCHEMICALS, CELLS, AND TISSUE CULTURE
RADIOTHERAPY
SOMATIC CELLS
SURVIVAL CURVES
X RADIATION