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Title: Laser modulation of human immune system: inhibition of lymphocyte proliferation by a gallium-arsenide laser at low energy

Journal Article · · Lasers Surg. Med.; (United States)
; ;

Cultured human lymphocytes were subjected to irradiation with a gallium-arsenide laser at energy fluence varying from 2.17 to 651 mJ/cm2, and the cell proliferation was assessed by (/sup 3/H)thymidine incorporation. Both mitogenic proliferation in response to phytohemagglutinin and spontaneous cell proliferation were markedly inhibited by the laser irradiation at energy fluence as low as 10.85 mJ/cm2. Similarly, the functional response of cells to antigen stimulation in a one-way mixed-lymphocyte reaction was also diminished as a result of laser irradiation. The results indicate that laser irradiation at low energy can interfere with immune system in vitro, and similar modulation could potentially occur in human subjects exposed to laser irradiation in vivo.

OSTI ID:
6174773
Journal Information:
Lasers Surg. Med.; (United States), Vol. 7:2
Country of Publication:
United States
Language:
English

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Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
LASER RADIATION
BIOLOGICAL EFFECTS
LYMPHOCYTES
CELL PROLIFERATION
RETICULOENDOTHELIAL SYSTEM
SENSITIVITY
ANTIGENS
DOSE-RESPONSE RELATIONSHIPS
IN VITRO
INHIBITION
LASERS
MAN
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AZINES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LEUKOCYTES
MAMMALS
MATERIALS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PRIMATES
PYRIMIDINES
RADIATIONS
RIBOSIDES
SOMATIC CELLS
TISSUES
VERTEBRATES
560400* - Other Environmental Pollutant Effects
551001 - Physiological Systems- Tracer Techniques