Inhibition of human lymphocyte proliferation by ultraviolet radiation: effects of ultraviolet B (290 to 320 nm) on T-lymphocytes, monocyte accessory function, and induction of suppressor mechanisms

Journal Article · Wed Jan 01 00:00:00 EST 1986 · J. Lab. Clin. Med.; (United States)

OSTI ID:5805312

Lederman, M M; Schacter, B; LeVine, M J; Ellner, J J

In vitro exposure of peripheral blood lymphocytes (PBLs) to doses of ultraviolet radiation (UVR) achievable during recreational sun exposure produces profound inhibition of lymphocyte blastogenesis. This study demonstrates that this inhibition is mediated by a direct dose-dependent effect on populations enriched for T-lymphocytes and is reversible after incubation of responder cells with phytohemagglutinin (PHA). In contrast, monocyte accessory function for both antigen- and mitogen-induced proliferation is relatively unaffected by in vitro exposure to UVR at doses up to 30 mJ/cm2. Exposure of PBL to UVR also results in the induction of a suppressor mechanism that inhibits the proliferation of unirradiated PBLs. In vitro exposure of human blood cells to UVR may provide a valuable tool for examining the cellular basis for the immunosuppressive effects of UVR.

• Research Organization: Univ. Hospitals of Cleveland, OH
• OSTI ID: 5805312
• Journal Information: J. Lab. Clin. Med.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LYMPHOCYTES
CELL PROLIFERATION
ULTRAVIOLET RADIATION
BIOLOGICAL EFFECTS
IMMUNOSUPPRESSION
IN VITRO
INHIBITION
MAN
MONOCYTES
PHENOTYPE
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
LEUKOCYTES
MAMMALS
MATERIALS
PRIMATES
RADIATIONS
SOMATIC CELLS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)