Receptor for immunoglobulin E on rat basophilic leukemia cells: effect of ligand binding on receptor expression

Journal Article · Fri Mar 01 04:00:00 EST 1985 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.82.5.1522· OSTI ID:6170029

Furuichi, K; Rivera, J; Isersky, C

The authors have evaluated the effect of ligand binding on expression of the receptor for IgE on rat basophilic leukemia (RBL) cells. RBL cells were grown in the presence or absence of /sup 131/I-labeled IgE and sometimes were also surface labeled with /sup 125/I. They found that cells grown in the presence of IgE continued to accumulate receptors at the surface and thus the apparent amount of cell-associated IgE continued to increase. The results obtained suggest that, in the presence of IgE, the elimination of the receptor from the surface was halted or slowed significantly while insertion into the membrane of previously synthesized receptor continued.

• Research Organization: National Institutes of Health, Bethesda, MD
• OSTI ID: 6170029
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 82:5; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GLOBULINS
HEMIC DISEASES
IMMUNOGLOBULINS
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE 131
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LEUKEMIA
MAMMALS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPES
RADIORECEPTOR ASSAY
RATS
RODENTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUMOR CELLS
VERTEBRATES