Dose-dependent radiation-induced hypotension in the canine

Technical Report · Wed Jan 01 04:00:00 EST 1986

OSTI ID:6169290

Cockerham, L G; Hampton, J D; Doyle, T F

Radiation-induced early transient incapacitation (ETI) is often accompanied by severe systemic hypotension. However, postradiation hypotension does not occur with equal frequency in all species and is not reported with consistency in the canine. In an attempt to clarify the differences in reported canine post-radiation blood pressures, canine systemic blood pressures were determined both before and after exposure to gamma radiation of either 80 or 100 Gy. Data obtained from six sham-radiated beagles and 12 radiated beagles indicated that 100-Gy, whole-body, gamma radiation produced a decrease in systemic mean blood pressure while 80-Gy, whole-body, gamma radiation did not. Analysis of this data could be consistent with a quantal response to a gamma radiation dose between 80 Gy and 100 Gy.

• Research Organization: Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
• OSTI ID: 6169290
• Report Number(s): AD-A-181849/1/XAB; AFRRI-SR-86-36
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD PRESSURE
DOGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
HYPOTENSION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
PHOTON BEAMS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
TRANSIENTS
VERTEBRATES
WHOLE-BODY IRRADIATION