RSU 1069, a 2-nitroimidazole containing an alkylating group: high efficiency as a radio- and chemosensitizer in vitro and in vivo
Electron affinity is the major factor influencing radiosensitizing efficiency in vitro. RSU 1069 has an electron affinity similar to misonidazole; however, the ability of this compound to sensitize hypoxic cells is considerably greater in vitro than that of misonidazole. Radiosensitization studies with the MT tumor in vivo also showed RSU 1069 to be a more efficient sensitizer than misonidazole. An administered dose of RSU 1069 yielded an enhancement of 1.8 to 1.9 using tumor cell survival and tumor cure as end-points. At least a 10-fold higher dose of misonidazole is required for a similar degree of sensitization. Low doses of RSU 1069 also radiosensitize the Lewis lung and B16 experimental tumors. The ability of RSU 1069 to potentiate the cytotoxic action of melphalan and other cytotoxic drugs towards the MT tumor was also examined. RSU 1069 given to mice 1 hour before melphalan gave an enhancement of 2.8.
- Research Organization:
- Medical Research Council, Harwell, England
- OSTI ID:
- 6166980
- Report Number(s):
- CONF-8311204-
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:9; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AFFINITY
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
AZOLES
CELL KILLING
CONNECTIVE TISSUE CELLS
DRUGS
ENDOXAN
FIBROBLASTS
HAMSTERS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IMMUNOSUPPRESSIVE DRUGS
IONIZING RADIATIONS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RODENTS
SOMATIC CELLS
TOXICITY
VERTEBRATES