Potentiation of melphalan activity in the KHT sarcoma by the radiosensitizer RSU 1069
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The radiation sensitizer misonidazole (MISO) has been shown to potentiate the cytotoxic action of a variety of anti-cancer agents. Even larger enhancement ratios than those observed with MISO have been found with certain other nitroimidazoles. One agent reported to be particularly effective in combination with the chemotherapeutic agent melphalan is the sensitizer RSU 1069. The present studies therefore were designed to evaluate the effect of combining these two agents in the treatment of intramuscularly growing KHT sarcomas. Tumor response was assessed using an in vivo to in vitro clonogenic cell survival assay. When given at times ranging from 60 min before to 30 min after melphalan exposure, RSU 1069 was found to increase the tumoricidal activity of the chemotherapeutic agent. Complete dose response curves combining RSU 1069 and a range of melphalan doses then were determined. For comparison the effects of combining MISO or benznidazole (BENZO) with melphalan also were evaluated. When combined with melphalan, doses of RSU 1069, BENZO and MISO were found to yield dose modifying factors of 1.6, 1.5, and 1.4, respectively. These results indicate that potentiation of melphalan activity occurs at RSU 1069 doses which are approximately 10-fold lower than those of MISO, making this sensitizer as effective a potentiator of melphalan as so far tested in the KHT sarcoma.
- Research Organization:
- Univ. of Rochester Cancer Center, NY
- OSTI ID:
- 6166976
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:9; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Toxicity of RSU-1069 for KHT cells treated in vivo or in vitro: evidence for a diffusible toxic product
Conference
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Sat Sep 01 00:00:00 EDT 1984
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:6166980
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Mon Feb 28 23:00:00 EST 1983
· Cancer Res.; (United States)
·
OSTI ID:6189536
Toxicity of RSU-1069 for KHT cells treated in vivo or in vitro: evidence for a diffusible toxic product
Journal Article
·
Fri Mar 31 23:00:00 EST 1989
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:6074101
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMAL CELLS
AZOLES
CELL KILLING
DATA
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
EXPERIMENTAL NEOPLASMS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
INFORMATION
NEOPLASMS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIOSENSITIVITY EFFECTS
SARCOMAS
TOXICITY
TUMOR CELLS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMAL CELLS
AZOLES
CELL KILLING
DATA
DISEASES
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
EXPERIMENTAL NEOPLASMS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
INFORMATION
NEOPLASMS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIOSENSITIVITY EFFECTS
SARCOMAS
TOXICITY
TUMOR CELLS