Bone marrow transfusions in previously irradiated, hematologically normal syngeneic mice
Journal Article
·
· Proc. Soc. Exp. Biol. Med.; (United States)
- Univ. of California, Berkeley
Transfusion of syngeneic marrow into normal, nonirradiated recipients results only in minimal proliferation of donor cells. However, irradiated recipients, restored to hematologic normalcy by an initial marrow transfusion, subsequently sustain proliferation which replaces approximately 10% of endogenous marrow after a single transfusion of 4 x 10/sup 7/ marrow cells of the same strain as the host. Cells from histoincompatible donors proliferate only rarely or minimally in the marrows of these irradiated, but hematologically normal recipients without reirradiation. Syngeneic male donor cells proliferate in irradiated and restored female mice, while female donor cells fail to proliferate in the marrow of syngeneic male recipients. A possible explanation is that transfused female cells respond immunologically to the abundant H-Y antigen in the male environment and are eliminated as a result.
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 6161750
- Journal Information:
- Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 166:3; ISSN PSEBA
- Country of Publication:
- United States
- Language:
- English
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· Ann. N.Y. Acad. Sci.; (United States)
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OSTI ID:5616135
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Thu Oct 31 23:00:00 EST 1985
· Exp. Hematol.; (United States)
·
OSTI ID:6254626
Special proliferative sites are not needed for seeding and proliferation of transfused bone marrow cells in normal syngeneic mice
Journal Article
·
Sun Aug 01 00:00:00 EDT 1982
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:5213830
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD CHEMISTRY
BONE MARROW CELLS
CELL PROLIFERATION
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
EXTERNAL IRRADIATION
IMMUNOSUPPRESSION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIOISOTOPES
RODENTS
SEX DEPENDENCE
SOMATIC CELLS
SYNERGISM
THERAPY
TIME DEPENDENCE
TRANSFUSIONS
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD CHEMISTRY
BONE MARROW CELLS
CELL PROLIFERATION
COBALT 60
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
EXTERNAL IRRADIATION
IMMUNOSUPPRESSION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
RADIATION EFFECTS
RADIOISOTOPES
RODENTS
SEX DEPENDENCE
SOMATIC CELLS
SYNERGISM
THERAPY
TIME DEPENDENCE
TRANSFUSIONS
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES