Radiopharmaceuticals for diagnosis and treatment: Progress report for the period November 1, 1968 through July 1, 1987

Technical Report · Wed Jul 01 04:00:00 EDT 1987

OSTI ID:6155423

Kuhl, D E

This project has been directed to the evolution of labeled chemicals useful for nuclear medical imaging to trace adrenal functions and localizing tumors in the neuroendocrine system. A major success was the introduction of T I-metaiodobenzylguanidine (MIBG). The uptake of radiolabeled precursors of epinephrine was explored. The uptake and excretion of five C-14 labeled precursors of epinephrine was studied in dogs. The adrenal medulla uptake of C-14 dopamine exceeded that of all other precursors. During the initial attempts to synthesize a successful adrenal medulla imaging agent, the concentration of C-14 dopamine in the human neuroblastoma was found to be considerably greater than in the normal human adrenal medulla. Radioiodinated bretylium analog was prepared that images the dog adrenal medulla. This effort was rapidly followed by the synthesis of original compounds with structural similarities to both norepinephrine and the adrenergic neuronal blocking agent, guanethidine; these latter agents demonstrating greater adrenal medulla specificity than the bretylium analogs. One of these guanidine derivatives, T I-metaiodobenzylguanidine (MIBG) has permitted the first successful diagnostic imaging of human adrenal medullary hyperplasia and of pheochromocytomas (including metastasized carcinoma) which could not be localized by any existing methodologies.

• Research Organization: Michigan Univ., Ann Arbor (USA). Div. of Nuclear Medicine
• DOE Contract Number: AC02-76EV02031
• OSTI ID: 6155423
• Report Number(s): DOE/EV/02031-17; ON: DE87013088
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
AUTONOMIC NERVOUS SYSTEM
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBON 11
CARBON ISOTOPES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
FLUORINE 18
FLUORINE ISOTOPES
GLIOMAS
HEART
HISTORICAL ASPECTS
HOURS LIVING RADIOISOTOPES
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
MEDICINE
METABOLISM
MIBG
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
PARASYMPATHOMIMETICS
POSITRON COMPUTED TOMOGRAPHY
RADIOCHEMISTRY
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
SPIPERONE
SYMPATHOMIMETICS
THERAPEUTIC USES
THERAPY
TOMOGRAPHY
USES