Aromatic radiofluorination with (/sup 18/F)fluorine gas: 6-(/sup 18/F)fluoro-L-dopa

Journal Article · Thu Nov 01 00:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6153611

Firnau, G; Chirakal, R; Garnett, E S

A new synthesis is described for the routine production of 3,4-dihydroxy-6-(/sup 18/F)fluoro-phenyl-L-alanine (6-(/sup 18/F)fluoro-L-dopa). The reaction between (/sup 18/F)fluorine gas and 3,4-dihydroxyphenyl-L-alanine (L-dopa) in liquid hydrogen fluoride gave 2-, 5-, and 6-(/sup 18/F)fluoro-L-dopa. 6-(/sup 18/F)Fluoro-L-dopa was isolated by reverse-phase high-pressure liquid chromatography. From 100 mCi (/sup 18/F)F/sub 2/, the method produces 3 mCi of 6-(/sup 18/F)fluoro-L-dopa at the end of synthesis.

• Research Organization: McMaster Univ. Medical Center, Hamilton, Ontario
• OSTI ID: 6153611
• Journal Information: J. Nucl. Med.; (United States), Vol. 25:11
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ALANINES
FLUORINATION
LABELLING
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
FLUORINE 18
HYDROFLUORIC ACID
LIQUID COLUMN CHROMATOGRAPHY
NMR SPECTRA
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
CHROMATOGRAPHY
DRUGS
FLUORINE ISOTOPES
HALOGENATION
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
INORGANIC ACIDS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
SEPARATION PROCESSES
SPECTRA
SYNTHESIS
550601* - Medicine- Unsealed Radionuclides in Diagnostics