Possible error-prone repair of neoplastic transformation induced by fission-spectrum neutrons
We have examined the effect of fission-spectrum neutrons from the JANUS reactor at Argonne National Laboratory, delivered either as acute or protracted irradiation, on the incidence of neoplastic transformation in the C3H 1OT1/2 mouse embryo cell line. Acute exposures were delivered at 10 to 38 rads/min, protracted exposures at 0.086 or 0.43 rad/min. The total doses for both ranged from 2.4 to 350 rads. In the low dose region (2.4 to 80 rads), there was a large enhancement in transformation frequency when the neutrons were delivered at the low dose rates compared with the high dose rates, but the survival of the cells was not significantly different between the two exposure conditions. Analysis of the initial parts of the curves shows that the regression line for protracted doses is about 9 times steeper than that for single acute exposures. Finally, the possibility is discussed that an error-prone repair process may be causing the enhanced transformation frequency by protracted neutron exposures. 12 references, 2 figures, 1 table.
- Research Organization:
- Argonne National Lab., IL (USA)
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 6152406
- Report Number(s):
- CONF-830782-5; ON: DE85005036
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ANIMAL CELLS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHRONIC EXPOSURE
DATA
DOSE-RESPONSE RELATIONSHIPS
ELEMENTARY PARTICLES
EMBRYOS
EXPERIMENTAL DATA
FERMIONS
FISSION NEUTRONS
HADRONS
INFORMATION
MAMMALS
MICE
NEUTRONS
NUCLEONS
NUMERICAL DATA
ONCOGENIC TRANSFORMATIONS
RADIATION EFFECTS
RADIOINDUCTION
RODENTS
SURVIVAL CURVES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ANIMAL CELLS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHRONIC EXPOSURE
DATA
DOSE-RESPONSE RELATIONSHIPS
ELEMENTARY PARTICLES
EMBRYOS
EXPERIMENTAL DATA
FERMIONS
FISSION NEUTRONS
HADRONS
INFORMATION
MAMMALS
MICE
NEUTRONS
NUCLEONS
NUMERICAL DATA
ONCOGENIC TRANSFORMATIONS
RADIATION EFFECTS
RADIOINDUCTION
RODENTS
SURVIVAL CURVES
VERTEBRATES