Evaluation of development toxicity data: a discussion of some pertinent factors and a proposal

Journal Article · Tue Mar 01 04:00:00 EST 1988 · Risk Anal.; (United States)

DOI:https://doi.org/10.1111/j.1539-6924.1988.tb01154.x· OSTI ID:6148193

Hart, W L; Reynolds, R C; Krasavage, W J; Ely, T S; Bell, R H; Raleigh, R L

There is currently no well-accepted standard method for evaluation of developmental toxicity data. This paper presents one approach to the evaluation of developmental toxicity data. The authors initially identify some pertinent factors that influence the interpretation of animal data and summarize the literature pertaining to these factors. Such factors include the quality and quantity of data and the relationship between maternal and developmental toxicity. They proceed with a discussion of quantitative assessment of data and propose schemes for qualitative and quantitative developmental hazard assessments.

• Research Organization: Eastman Kodak Co., Rochester, NY (USA)
• OSTI ID: 6148193
• Journal Information: Risk Anal.; (United States), Journal Name: Risk Anal.; (United States) Vol. 8:1; ISSN RIAND
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ALUMINIUM CHLORIDES
ALUMINIUM COMPOUNDS
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
CHLORIDES
CHLORINATED ALIPHATIC HYDROCARBONS
CHLORINE COMPOUNDS
CHLOROFORM
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
EVALUATION
FEMALES
HALIDES
HALOGEN COMPOUNDS
HALOGENATED ALIPHATIC HYDROCARBONS
HAZARDS
HEALTH HAZARDS
HUMAN POPULATIONS
HYDROXY COMPOUNDS
INFORMATION VALIDATION
LEAD
MAMMALS
MAN
MATERIALS
MERCURY COMPOUNDS
METALS
OCCUPATIONAL EXPOSURE
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC MERCURY COMPOUNDS
PHENOLS
POPULATIONS
PREGNANCY
PRENATAL EXPOSURE
PRIMATES
REPRODUCTION
RISK ASSESSMENT
TESTING
TOXIC MATERIALS
TOXICITY
VALIDATION
VERTEBRATES
WOMEN