Differentiation of strains of varicella-zoster virus by changes in neutral lipid metabolism in infected cells

Journal Article · Fri Feb 28 23:00:00 EST 1986 · J. Virol.; (United States)

OSTI ID:6145891

Jerkofsky, M; De Siervo, A J

Eleven isolates of varicella-zoster virus were tested for their effects on the incorporation of (/sup 14/C)acetate into lipids in infected human embryonic lung cells. By relative percent, all virus isolates demonstrated a shift from polar lipid synthesis to neutral lipid, especially triglyceride, synthesis. By data expressed as counts per minute per microgram of protein, the VZV strains could be separated into two groups: those strains which depressed lipid synthesis and those strains which did not depress, and may even have stimulated, lipid, especially triglyceride, synthesis. These results may be useful in understanding the development of lipid changes seen in children affected with Reye's syndrome following chickenpox.

• Research Organization: Univ. of Maine, Orono (USA)
• OSTI ID: 6145891
• Journal Information: J. Virol.; (United States), Journal Name: J. Virol.; (United States) Vol. 57:3; ISSN JOVIA
• Country of Publication: United States
• Language: English

Related Subjects

550701* -- Microbiology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACETATES
ANIMAL CELLS
ANIMALS
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACID SALTS
DISEASES
HERPES ZOSTER
INFECTIOUS DISEASES
LABELLED COMPOUNDS
LIPIDS
LUNGS
MAMMALS
MAN
METABOLISM
MICROORGANISMS
NERVOUS SYSTEM DISEASES
ORGANIC COMPOUNDS
ORGANS
PARASITES
PATHOGENESIS
PRIMATES
RESPIRATORY SYSTEM
RESPIRATORY TRACT CELLS
UPTAKE
VERTEBRATES
VIRAL DISEASES
VIRUSES