Identification of the ancestral haplotype for apolipoprotein B suggests an African origin of Homo sapiens sapiens and traces their subsequent migration to Europe and the Pacific

Journal Article · Fri Feb 15 04:00:00 EST 1991 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.88.4.1403· OSTI ID:6144934

Rapacz, J; Hasler-Rapacz, J O ^[1]; Chen, L; Wu, Mingjiuan; Schumaker, V N ^[2]; Butler-Brunner, E; Butler, R ^[3]

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1. Univ. of Wisconsin, Madison (United States)
2. Univ. of California, Los Angeles (United States)
3. Swiss Red Cross Blood Transfusion Service, Bern (Switzerland)

The probable ancestral haplotype for human apolipoprotein B (apoB) has been identified through immunological analysis of chimpanzee and gorilla serum and sequence analysis of their DNA. Moreover, the frequency of this ancestral apoB haplotype among different human populations provides strong support for the African origin of Homo sapiens sapiens and their subsequent migration from Africa to Europe and to the Pacific. The approach used here for the identification of the ancestral human apoB haplotype is likely to be applicable to many other genes.

• OSTI ID: 6144934
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (United States) Vol. 88:4; ISSN 0027-8424; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
APOLIPOPROTEINS
ASIA
BIOLOGICAL EVOLUTION
DNA SEQUENCING
EUROPE
HUMAN POPULATIONS
IMMUNOLOGY
LIPIDS
LIPOPROTEINS
MIGRATION
ORGANIC COMPOUNDS
POPULATIONS
PROTEINS
RFLPS
STRUCTURAL CHEMICAL ANALYSIS