(Mutagenicity of radon and radon daughters)

Technical Report · Sun Dec 31 23:00:00 EST 1989

DOI:https://doi.org/10.2172/6141035· OSTI ID:6141035

The current objective of our research is to investigate the dose-response relationship of the lethal and mutagenic effects of exposure of cells to radon and its decay products. Dose-rate dependence will be studied, as well as the nature of the DNA lesions. The effect of DNA repair on the lethal and mutagenic effects of exposure and on the character of the DNA lesions will be investigated by comparing the response of L5178Y strains which differ in their ability to rejoin X radiation-induced DNA double-strand breaks. This report discusses progress incurred from 4/1/1988--10/1/1990. 5 refs., 9 figs., 6 tabs.

• Research Organization: Case Western Reserve Univ., Cleveland, OH (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG02-88ER60658
• OSTI ID: 6141035
• Report Number(s): DOE/ER/60658-3; ON: DE91005591
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDUCTS
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL CULTURES
COUNTING TECHNIQUES
DAUGHTER PRODUCTS
DAYS LIVING RADIOISOTOPES
DNA ADDUCTS
DNA REPAIR
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
EVEN-EVEN NUCLEI
HEAVY NUCLEI
IONIZING RADIATIONS
ISOTOPES
LETHAL DOSES
MAMMALS
MICE
MORTALITY
MUTAGENESIS
NUCLEI
PROGRESS REPORT
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADON 222
RADON ISOTOPES
RECOVERY
REPAIR
RODENTS
SCINTILLATION COUNTING
STRAND BREAKS
TOXICITY
VERTEBRATES
X RADIATION