Radionuclide distribution dynamics in skeletons of beagles fed 90Sr: Correlation with injected 226Ra and 239Pu

Journal Article · Fri Mar 01 00:00:00 EST 1991 · Health Physics; (USA)

DOI:https://doi.org/10.1097/00004032-199103000-00003· OSTI ID:6140178

Parks, N J ^[1]

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1. Univ. of California, Davis (USA)

Data for the bone-by-bone redistribution of 90Sr in the beagle skeleton are reported for a period of 4000 d following a midgestation-to-540-d-exposure by ingestion. The partitioned clearance model (PCM) that was originally developed to describe bone-by-bone radionuclide redistribution of 226Ra after eight semimonthly injections at ages 435-535 d has been fitted to the 90Sr data. The parameter estimates for the PCM that describe the distribution and clearance of 226Ra after deposition on surfaces following injection and analogous parameter estimates for 90Sr after uniform deposition in the skeleton as a function of Ca mass are given. Fractional compact bone masses per bone group (mi,COM) are also predicted by the model and compared to measured values; a high degree of correlation (r = 0.84) is found. Bone groups for which the agreement between the model and experimental values of mi,COM was poor had tissue-to-calcium weight ratios about 1.5 times those for bones that agreed well. Metabolically defined surface in PCM is initial activity fraction per Ca fraction in a given skeletal component for intravenously injected alkaline earth (Sae) radionuclides; comparisons are made to similarly defined surface (Sact) values from 239Pu injection studies. The patterns of Sae and Sact distribution throughout the skeleton are similar.

• OSTI ID: 6140178
• Journal Information: Health Physics; (USA), Vol. 60:3; ISSN 0017-9078
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
PLUTONIUM 239
UPTAKE
RADIUM 226
SKELETON
RADIONUCLIDE KINETICS
STRONTIUM 90
BEAGLES
INTRAVENOUS INJECTION
METABOLISM
ORAL ADMINISTRATION
PREGNANCY
TISSUE DISTRIBUTION
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBON 14 DECAY RADIOISOTOPES
DISTRIBUTION
DOGS
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
HEAVY ION DECAY RADIOISOTOPES
HEAVY NUCLEI
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
NUCLEI
ORGANS
PLUTONIUM ISOTOPES
RADIOISOTOPES
RADIUM ISOTOPES
STRONTIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells