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Title: Kinetic basis for compensated hemopoiesis during continuous irradiation with low doses. [. gamma. rays; mice]

Abstract

The hemopoietic effects of low-level continuous ..gamma.. irradiation with a daily regime of 16.0, 2.5, 1.4, and 1.15 rad were studied in mice. Irradiation time varied from 3 to 38 days. During the irradiation in vivo TL dosimetry was applied. Between 43 and 50 rad the reduction in both erythropoiesis and the number of femoral colony-forming cells (CFU/sub 8/) were inversely related to irradiation time. If exposure time was extended to over 30 days, /sup 59/Fe uptake and stem cell level practically agreed with those of the control indicating a compensation within the hemopoietic system. At the same time, however, a significantly increased proliferation rate of CFU/sub 8/ was found. The threshold dose for a detectable increase in CFU/sub 8/ turnover rate was observed to be about 30 rad at 2.5 rad daily dose. The results suggest the following conclusions. (1) In spite of the virtually unaltered hemopoiesis during the low-level chronic irradiation, characteristic changes can be detected in the turnover rate of the CFU/sub 8/ population. Therefore, the number of CFU/sub 8/ in S phase is proposed to be a suitable tool for the investigation of the effects of low-level irradiation. (2) The significantly enhanced proliferation rate of CFU/submore » 8/ can be regarded as the basis for the maintenance of the normal stem cell level and hemopoiesis during low-level irradiation.« less

Authors:
; ;
Publication Date:
Research Org.:
National Research Inst. for Radiobiology and Radiohygiene, Budapest, Hungary
OSTI Identifier:
6137816
Resource Type:
Journal Article
Journal Name:
Radiat. Res.; (United States)
Additional Journal Information:
Journal Volume: 77:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BLOOD FORMATION; BIOLOGICAL RADIATION EFFECTS; CFU; POPULATION DYNAMICS; ERYTHROPOIESIS; LOW DOSE IRRADIATION; RISK ASSESSMENT; STEM CELLS; ACUTE IRRADIATION; CHRONIC IRRADIATION; COBALT 60; COMPARATIVE EVALUATIONS; EXPERIMENTAL DATA; GAMMA RADIATION; ISOLATED VALUES; MICE; WHOLE-BODY IRRADIATION; ACUTE EXPOSURE; ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; CHRONIC EXPOSURE; COBALT ISOTOPES; DATA; DATA FORMS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; INFORMATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; NUMERICAL DATA; ODD-ODD NUCLEI; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RODENTS; SOMATIC CELLS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Gidali, J., Bojtor, I., and Feher, I. Kinetic basis for compensated hemopoiesis during continuous irradiation with low doses. [. gamma. rays; mice]. United States: N. p., 1979. Web. doi:10.2307/3575140.
Gidali, J., Bojtor, I., & Feher, I. Kinetic basis for compensated hemopoiesis during continuous irradiation with low doses. [. gamma. rays; mice]. United States. doi:10.2307/3575140.
Gidali, J., Bojtor, I., and Feher, I. Thu . "Kinetic basis for compensated hemopoiesis during continuous irradiation with low doses. [. gamma. rays; mice]". United States. doi:10.2307/3575140.
@article{osti_6137816,
title = {Kinetic basis for compensated hemopoiesis during continuous irradiation with low doses. [. gamma. rays; mice]},
author = {Gidali, J. and Bojtor, I. and Feher, I.},
abstractNote = {The hemopoietic effects of low-level continuous ..gamma.. irradiation with a daily regime of 16.0, 2.5, 1.4, and 1.15 rad were studied in mice. Irradiation time varied from 3 to 38 days. During the irradiation in vivo TL dosimetry was applied. Between 43 and 50 rad the reduction in both erythropoiesis and the number of femoral colony-forming cells (CFU/sub 8/) were inversely related to irradiation time. If exposure time was extended to over 30 days, /sup 59/Fe uptake and stem cell level practically agreed with those of the control indicating a compensation within the hemopoietic system. At the same time, however, a significantly increased proliferation rate of CFU/sub 8/ was found. The threshold dose for a detectable increase in CFU/sub 8/ turnover rate was observed to be about 30 rad at 2.5 rad daily dose. The results suggest the following conclusions. (1) In spite of the virtually unaltered hemopoiesis during the low-level chronic irradiation, characteristic changes can be detected in the turnover rate of the CFU/sub 8/ population. Therefore, the number of CFU/sub 8/ in S phase is proposed to be a suitable tool for the investigation of the effects of low-level irradiation. (2) The significantly enhanced proliferation rate of CFU/sub 8/ can be regarded as the basis for the maintenance of the normal stem cell level and hemopoiesis during low-level irradiation.},
doi = {10.2307/3575140},
journal = {Radiat. Res.; (United States)},
number = ,
volume = 77:2,
place = {United States},
year = {1979},
month = {2}
}