Nutritional significance of the Cu:Mo interrelationship to ruminants and non-ruminants
Mo has been shown to interfere with the Cu metabolism of several species but the interrelationship is thought to be of practical significance only to ruminants when herbage Mo concentrations exceed 5 ppM. Evidence has been obtained that Mo interferes with Cu metabolism in both ruminants and non-ruminants at concentrations below 5 ppM and within a range encountered in foods for human consumption. Groups of hypocupraemic ewes were repleted with a semi-purified diet containing 8 mgCu/kg and one of four levels of dietary Mo, 0.5, 2.5, 4.5 and 8.5 mg/kg. Rate of recovery in plasma Cu was used as a measure of the efficiency of Cu utilization and successive increments in dietary Mo were found to decrease that efficiency by 40, 80 and 40%, respectively. The results suggest that differences of 1 mg/kg in dietary Mo are of biological significance to ruminants. When groups of Cu-depleted guinea pigs were subjected to repletion with diets containing 8 mg Cu/kg and 0.6, 4.1, 26 or 104 mg Mo/kg the lowest increment in Mo, 3.5 mg/kg, decreased the response in liver Cu as much as the highest, 75 mg/kg, a reduction fo 23% being recorded. The industrial uses of Mo make it a potential contaminant of man's environment and Mo concentrations > 4 mg/kg have been reported in vegetables and meats. The possibility that the Cu:Mo interrelationship influences Cu metabolism in man should therefore be re-examined. 20 references, 3 tables.
- Research Organization:
- Moredun Research Inst., Edinburgh, Scotland
- OSTI ID:
- 6133381
- Report Number(s):
- CONF-730613-
- Journal Information:
- Trace Subst. Environ. Health; (United States), Vol. 7; Conference: 7. annual conference on trace substances in environmental health, Columbia, MO, USA, 12 Jun 1973
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
MOLYBDENUM
BIOLOGICAL EFFECTS
COPPER
GUINEA PIGS
HEALTH HAZARDS
INHIBITION
METABOLISM
SHEEP
ANIMALS
DOMESTIC ANIMALS
ELEMENTS
HAZARDS
MAMMALS
METALS
RODENTS
RUMINANTS
TRANSITION ELEMENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)