Studies on aerosols. I. Reduction of dust deposition in lungs of rabbits by aqueous aerosols
Rabbits were exposed to air containing 0.01 to 0.04 mg/liter zinc silicate dust with a mean diameter of 0.9 ..mu..m. Irregular breathing with some cyanosis after 2 hr was observed. Pulmonary changes after 4.5 to 5 hr included bronchitis, patchy atelectasis, emphysema, interstitial pneumonitis (thickening of septa, moderate congestion, infiltration of mononuclear cells and polymorphonuclear leukocytes). After 1, 7, or 14 days recovery there were no or only slight pulmonary problems. There was localization of particles at surfaces facing, deflecting or slowing air currents, particularly near pleura and hilus and less in central portion of lobes. Rabbits exposed to above dust plus aqueous wetting agent aerosol averaging 0.5 ..mu..m in diameter showed no cyanosis or marked respiratory difficulty. Rabbits showed less of above pulmonary changes and lesser amount of dust in lungs, particularly in alveoli and alveolar ducts. Most particles were cleared in 1 day in both groups, especially aerosol group, and essentially were all gone after 7 days. Differences were primarily due to coating of particles with liquid (increased size) and aggregation.
- OSTI ID:
- 6131971
- Journal Information:
- J. Ind. Hyg. Toxicol.; (United States), Vol. 30
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
DUSTS
DEPOSITION
AEROSOLS
BRONCHITIS
CLEARANCE
EMPHYSEMA
LUNGS
PARTICLE SIZE
PARTICLES
PATHOLOGICAL CHANGES
PNEUMONITIS
RABBITS
RESPIRATORY SYSTEM DISEASES
RETENTION
ZINC SILICATES
ANIMALS
BODY
COLLOIDS
DISEASES
DISPERSIONS
MAMMALS
ORGANS
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM
SILICATES
SILICON COMPOUNDS
SIZE
SOLS
VERTEBRATES
ZINC COMPOUNDS
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)