Influence of elastase-induced emphysema and the inhalation of an irritant aerosol on deposition and retention of an inhaled insoluble aerosol in Fischer-344 rats

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(83)90315-0· OSTI ID:5718447

Damon, E G; Mokler, B V; Jones, R K

The purpose of this study was to assess the effects of elastase-induced pulmonary emphysema and the inhalation of an irritant aerosol (Triton X-100, a nonionic surfactant similar to those used in a number of pressurized consumer products) on pulmonary deposition and retention of an insoluble test aerosol, /sup 59/FE-labeled Fe/sub 2/O/sub 3/. Untreated rats or rats pretreated by intratracheal in stillation with elastase were exposed to an aerosol of /sup 59/Fe-labeled Fe/sub 2/O/sub 3/ either 18 hr or 7 days after exposure to aerosslized Triton X-100 which was administered in doses of 20, 100, or 200 ..mu..g/g of lung. Rats pretreated with elastase had significantly lower pulmonary deposition of /sup 59/Fe than the untreated controls (p < 0.005). Pulmonary deposition of Fe/sub 2/O/sub 3/ was unaffected by pretreatment with Triton X-100. Elastase treatment alone had no effect on retention of Fe/sub 2/O/sub 3/. Triton X-100 administered 18 hr prior to exposure of rats to Fe/sub 2/O/sub 3/ aerosol resulted in dose-related increases in whole-body retention of /sup 59/Fe. When rats were exposed to Triton X-100 7 days before exposure to Fe/sub 2/O/sub 3/, increased retention of /sup 59/Fe was noted only in those treated at the highest Triton X-100 dose level (200 ..mu..g/g). 20 references, 5 tables.

• Research Organization: Inhalation Toxicology Research Institute, Albuquerque, NM
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 5718447
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 67; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

550901 -- Pathology-- Tracer Techniques
560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
COLLOIDS
DATA
DAYS LIVING RADIOISOTOPES
DISEASES
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
EMPHYSEMA
ENZYMES
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
HYDROLASES
INFORMATION
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
IRON
IRON 59
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LUNGS
MAMMALS
METALS
NUCLEI
NUMERICAL DATA
ORGANS
PEPTIDE HYDROLASES
RADIOISOTOPES
RATS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RETENTION
RODENTS
SERINE PROTEINASES
SOLS
SURFACTANTS
TRACER TECHNIQUES
TRANSITION ELEMENTS
VERTEBRATES