Analysis of potential carcinogenic risk from formaldehyde

Journal Article · Fri Jun 01 04:00:00 EDT 1984 · Regul. Toxicol. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0273-2300(84)90034-5· OSTI ID:6128599

Squire, R A; Cameron, L L

Formaldehyde was recently shown to be carcinogenic in the nasal cavities of rats and mice following chronic inhalation at vapor concentrations which were cytotoxic. The epidemiological, physiological, and toxicological data on formaldehyde are evaluated as they pertain to the analysis of carcinogenic risk. It is concluded that humans are likely to be less susceptible than test rodents to potential carcinogenic effects and that the risk at low-level exposure would not be linearly related to that observed at the higher levels which were found to be carcinogenic in animals. Risk assessment procedures and risk management decisions should incorporate all of the relevant biological information, such as that discussed, rather than rely solely on a mathematical approach which is likely to yield inaccurate and misleading conclusions.

• Research Organization: Johns Hopkins Univ. School of Medicine, Baltimore, MD
• OSTI ID: 6128599
• Journal Information: Regul. Toxicol. Pharmacol.; (United States), Journal Name: Regul. Toxicol. Pharmacol.; (United States) Vol. 4:2; ISSN RTOPD
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CARCINOGENESIS
DISEASES
EPIDEMIOLOGY
FACE
FORMALDEHYDE
HEAD
INHALATION
INTAKE
MAMMALS
MAN
MICE
NEOPLASMS
NOSE
OCCUPATIONAL DISEASES
ORGANIC COMPOUNDS
PATHOGENESIS
PRIMATES
RATS
RESPIRATORY SYSTEM
RISK ASSESSMENT
RODENTS
VERTEBRATES