Isolation and characterization of a new zinc-binding protein from albacore tuna plasma
Journal Article
·
· Biochemistry; (United States)
The protein responsible for sequestering high levels of zinc in the plasma of the albacore tuna (Thunnus alalunga) has been isolated by sequential chromatography. The glycoprotein has a molecular weight of 66,000. Approximately 8.2% of its amino acid residues are histidines. Equilibrium dialysis experiments show it to bind 3 mol of zinc/mol of protein. The stoichiometric constant for the association of zinc with a binding site containing three histidines was determined to be 10/sup 9.4/. This protein is different from albumin and represents a previously uncharacterized zinc transport protein.
- Research Organization:
- Univ. of California, San Diego, La Jolla
- OSTI ID:
- 6127312
- Journal Information:
- Biochemistry; (United States), Vol. 26:11
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
GLUCOPROTEINS
BIOCHEMISTRY
PURIFICATION
ZINC 65
MEMBRANE TRANSPORT
ZINC CHLORIDES
AMINO ACID SEQUENCE
ELECTROPHORESIS
RADIOCHROMATOGRAPHY
TUNA
ANIMALS
AQUATIC ORGANISMS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOHYDRATES
CHEMISTRY
CHLORIDES
CHLORINE COMPOUNDS
CHROMATOGRAPHY
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FISHES
HALIDES
HALOGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
MOLECULAR STRUCTURE
NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPES
SACCHARIDES
SEPARATION PROCESSES
VERTEBRATES
ZINC COMPOUNDS
ZINC HALIDES
ZINC ISOTOPES
550201* - Biochemistry- Tracer Techniques
GLUCOPROTEINS
BIOCHEMISTRY
PURIFICATION
ZINC 65
MEMBRANE TRANSPORT
ZINC CHLORIDES
AMINO ACID SEQUENCE
ELECTROPHORESIS
RADIOCHROMATOGRAPHY
TUNA
ANIMALS
AQUATIC ORGANISMS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOHYDRATES
CHEMISTRY
CHLORIDES
CHLORINE COMPOUNDS
CHROMATOGRAPHY
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FISHES
HALIDES
HALOGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
MOLECULAR STRUCTURE
NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPES
SACCHARIDES
SEPARATION PROCESSES
VERTEBRATES
ZINC COMPOUNDS
ZINC HALIDES
ZINC ISOTOPES
550201* - Biochemistry- Tracer Techniques