Estimation of cerebral oxygen utilization rate by single-bolus /sup 15/O/sub 2/ inhalation and dynamic positron emission tomography
This study shows that regional CMRO/sub 2/ can be estimated by means of nonlinear regression using dynamic positron emission tomographic data acquired during 1 min following single-bolus inhalation of /sup 15/O/sub 2/. The feasibility of simultaneous estimation of CBF, cerebral blood volume (CBV), oxygen extraction ratio (OER), and CMRO/sub 2/ was assessed by simulations using the model of Mintun et al. Four oxygen metabolic measurements, each consisting of a CBF, CBV, and /sup 15/O/sub 2/ bolus study, were carried out on three volunteers. Regional values for CBF, CBV, OER, and CMRO/sub 2/ were derived in two ways: from the fits of the time-activity curves of the dynamic /sup 15/O/sub 2/ bolus study alone (CMRO/sub 2/(fit)) and from the three separate studies (CMRO/sub 2/ (control)). For the 56 regions of interest analyzed, using a fit interval of 60 s, CMRO/sub 2/(fit) was 93.4 +/- 7.8% of CMRO/sub 2/(control) (mean +/- SD) with a correlation coefficient of r = 0.95. CMRO/sub 2/(control) ranged from 87 to 290 mumol/min/100 g. Individual simultaneous estimates of CBF, CBV, and OER were not reliable. Finally, we found that the validity of the model was limited in practice to the first minute after tracer inhalation.
- Research Organization:
- Montreal Neurological Institute and Hospital, Quebec
- OSTI ID:
- 6124821
- Journal Information:
- J. Cereb. Blood Flow Metab.; (United States), Vol. 7:4
- Country of Publication:
- United States
- Language:
- English
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550601* - Medicine- Unsealed Radionuclides in Diagnostics