The measurement of sequential changes in cerebral blood flow and oxygen metabolism by positron computed tomography with continuous inhalation of oxygen-15 labeled gases

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6930708

Tanada, S; Yonekura, Y; Senda, M; Nishimura, K; Tamaki, N; Saji, H; Fujita, T; Kobayashi, A; Taki, W; Ishikawa, M

The use of continuous inhalation of oxygen-15 labeled gases is a widely accepted method to measure regional cerebral blood flow (CBF) and oxygen metabolism (CMRO/sub 2/) with positron computed tomography (PCT). The purpose of this study is to evaluate the feasibility to measure sequential changes in CBF and CMRO/sub 2/ by PCT. The functional images of CBF, oxygen extraction fraction (OEF), and CMRO/sub 2/ were obtained using continuous inhalation of oxygen-15 labeled carbon dioxide and oxygen. The effects of spinal drainage in CBF and CMRO/sub 2/ were studied in patients with hydrocephalus following subarachnoid hemorrhage due to the rupture of intracranial aneurysm. Following the measurement in control state, 20 ml of cerebrospinal fluid (CSF) were withdrawn gradually through lumbar puncture, and sequential PCT scans were performed. CBF and CMRO/sub 2/ were markedly depressed in the case with hydrocephalus. The drainage of CSF significantly improved OEF and CMRO/sub 2/, whereas CBF remained depressed. In patients with chronic cerebrovascular disease, the changes in CBF were studied with inhalation of 5% carbon dioxide (CO/sub 2/). CO/sub 2/ loading demonstrated the increase in CBF, while poor regional increase was observed in ''moyamoya'' disease, which permitted the assessment of vascular response to the elevation of plasma CO/sub 2/. The authors preliminary work indicated the potential usefulness of sequential PCT to study the changes in CBF and CMRO/sub 2/ with various interventions.

• Research Organization: Kyoto Univ. School of Medicine, Kyoto
• OSTI ID: 6930708
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DRAINAGE
ELEMENTS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
EXTRACTION
FEASIBILITY STUDIES
HEMORRHAGE
IMAGES
INHALATION
INTAKE
ISOTOPES
LABELLING
LIGHT NUCLEI
MALFORMATIONS
METABOLISM
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NONMETALS
NUCLEI
ORGANS
OXIDES
OXYGEN
OXYGEN 15
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
PATHOLOGICAL CHANGES
PATIENTS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
SEPARATION PROCESSES
SKELETON
SYMPTOMS
TOMOGRAPHY
USES
VERTEBRAE