Gynecologic cancer treatment: risk factors for therapeutically induced neoplasia

Conference · Tue Jul 15 04:00:00 EDT 1980 · Cancer, Suppl.; (United States)

OSTI ID:6120482

Messerschmidt, G L; Hoover, R; Young, R C

Therapeutic intervention in a course of illness, while producing the desired result, also may have some adverse long-term effects on the patient. Second malignancies are one of the known complications of therapy. The treatments of gynecologic cancers by surgery, irradiation and chemotherapy have been associated with subsequent neoplasms. The use of normal skin from the thigh to fabricate an artificial vagina has resulted in more squamous cell carcinomas than expected. Alkylating agents used in the treatment of ovarian cancer and other diseases have been shown to lead to an increased risk of leukemia. The incidence of lymphoma and uterine, urinary bladder and colon carcinomas has been associated with prior irradiation for gynecologic disease. The literature regarding the therapeutically induced risk factors in gynecologic therapy is reviewed and areas of our knowledge that require more investigation are identified.

• Research Organization: National Cancer Inst., Bethesda, MD
• OSTI ID: 6120482
• Conference Information: Journal Name: Cancer, Suppl.; (United States) Journal Volume: 48:2
• Country of Publication: United States
• Language: English

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560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLADDER
BODY
CHEMOTHERAPY
CHROMIUM COMPOUNDS
CHROMIUM PHOSPHATES
DAYS LIVING RADIOISOTOPES
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
FEMALE GENITALS
GASTROINTESTINAL TRACT
HEMIC DISEASES
INTERMEDIATE MASS NUCLEI
INTESTINES
IODINE 131
IODINE ISOTOPES
ISOTOPES
LARGE INTESTINE
LEUKEMIA
LIGHT NUCLEI
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
OXYGEN COMPOUNDS
PATIENTS
PHOSPHATES
PHOSPHORUS 32
PHOSPHORUS COMPOUNDS
PHOSPHORUS ISOTOPES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RISK ASSESSMENT
SIDE EFFECTS
SURGERY
THERAPY
TRANSITION ELEMENT COMPOUNDS
URINARY TRACT
UTERUS