Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Gynecologic cancer treatment: risk factors for therapeutically induced neoplasia

Journal Article · · Cancer (Philadelphia); (United States)
; ;
Therapeutic intervention in a course of illness, while producing the desired result, also may have some adverse long-term effects on the patient. Second malignancies are one of the known complications of therapy. The treatments of gynecologic cancers by surgery, irradiation and chemotherapy have been associated with subsequent neoplasms. Care must be exercised in associating previous therapy and a subsequent malignancy. Naturally occurring second cancers must be separated from those which are iatrogenic. Associations in the literature have been made involving malignancies as a sequelae of prior gynecologic therapy. The use of normal skin from the thigh to fabricate an artificial vagina has resulted in more squamous cell carcinomas than expected. Alkylating agents used in the treatment of ovarian cancer and other diseases have been shown to lead to an increased risk of leukemia. Irradiation therapy, however, has not yet been shown to be related to leukemia in cervical cancer patients. The incidence of lymphoma and uterine, urinary bladder and colon carcinomas has been associated with prior irradiation for gynecologic disease. The literature regarding the therapeutically induced risk factors in gynecologic therapy is reviewed and areas of our knowledge that require more investigation are identified.
OSTI ID:
5365820
Journal Information:
Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 48:2; ISSN CANCA
Country of Publication:
United States
Language:
English

Similar Records

Gynecologic cancer treatment: risk factors for therapeutically induced neoplasia
Conference · Tue Jul 15 00:00:00 EDT 1980 · Cancer, Suppl.; (United States) · OSTI ID:6120482
Carcinoma of vagina 10 or more years following pelvic irradiation therapy
Journal Article · Mon Feb 28 23:00:00 EST 1977 · Am. J. Obstet. Gynecol.; (United States) · OSTI ID:7120492
Treatment-related cancers after gynecologic malignancy
Journal Article · Thu Oct 15 00:00:00 EDT 1987 · Cancer (Philadelphia); (United States) · OSTI ID:5716441

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
FEMALE GENITALS
GYNECOLOGY
HEMIC DISEASES
LEUKEMIA
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
SIDE EFFECTS
THERAPY