Occult thyrotoxicosis: a correctable cause of idiopathic atrial fibrillation
Serum total thyroxine, triiodothyronine and thyrotropin response to thyrotropin-releasing hormone were measured in 75 consecutive patients presenting to a cardiology clinic with atrial fibrillation with no obvious cardiovascular cause. A lack of response of serum thyrotropin to thyrotropin-releasing hormone, indicative of thyrotoxicosis, was found in 10 patients (13%), not all whom had raised serum thyroid hormone levels. These 10 patients were predominantly male, had no clinical signs of thyrotoxicosis and a relative excess of nonpalpable autonomous thyroid nodules demonstrated with scintigraphy. Eight of the 10 patients had reversion to stable sinus rhythm after treatment with iodine-131 or carbimazole, either spontaneously or after direct current cardioversion. It would appear that clinically occult thyrotoxicosis can be identified consistently only with the thyrotropin-releasing hormone test and is the cause of idiopathic atrial fibrillation in a significant proportion of patients.
- Research Organization:
- Royal Infirmary, Edinburgh, Scotland
- OSTI ID:
- 6113575
- Journal Information:
- Am. J. Cardiol.; (United States), Vol. 44:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
IODINE 131
PHARMACOLOGY
THYROID
DYNAMIC FUNCTION STUDIES
BLOOD
CEREBRUM
DIAGNOSIS
MYOCARDIAL INFARCTION
PATHOLOGICAL CHANGES
THERAPY
THYROXINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
BRAIN
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MATERIALS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PEPTIDE HORMONES
RADIOISOTOPES
THYROID HORMONES
560161* - Radionuclide Effects
Kinetics
& Toxicology- Man