Radioprotection of mouse skin vasculature and the RIF-1 fibrosarcoma by WR-2721
The degree of radioprotection obtained with WR-2721 is critically dependent upon the oxygen tension of the tissue concerned. It was therefore considered of interest to examine the response of vascular tissue, which would be supposedly well oxygenated, to treatment with WR-2721 plus X rays. The response of this tissue is of interest because of its role in late radiation damage. In addition, for therapeutic gain an agent must protect normal tissue without concomitant tumor protection. However, data on tumor radioprotection have been conflicting and therefore the effect of WR-2721 on an experimental tumor was also tested. Vascular damage was assessed using the fact that tumors grow more slowly in irradiated beds (Tumor Bed Effect). WR-2721 injected 30 minutes before 5 to 30 Gy X rays protected skin stroma by a factor of 1.6. However, WR-2721 given 10 to 60 minutes before 20 Gy X rays to the RIF-1 tumor had either no effect or was protective, according to the method of immobilizing the mice during irradiation.
- Research Organization:
- St. Thomas's Hospital Medical School, London, England
- OSTI ID:
- 6109772
- Report Number(s):
- CONF-8311204-
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 10:9; Conference: Conference on chemical modifiers of cancer treatment, Banff, Alberta, Canada, 27 Nov 1983
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BLOOD VESSELS
BIOLOGICAL RADIATION EFFECTS
EXPERIMENTAL NEOPLASMS
THIOLS
RADIOSENSITIVITY EFFECTS
FIBROSARCOMAS
MICE
OXYGEN
RADIOPROTECTIVE SUBSTANCES
SKIN
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARDIOVASCULAR SYSTEM
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
IONIZING RADIATIONS
MAMMALS
NEOPLASMS
NONMETALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
SARCOMAS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals