Radioprotection of normal tissues against gamma rays and cyclotron neutrons with WR-2721: LD/sub 50/ studies and /sup 35/S-WR-2721 biodistribution

Journal Article · Thu Mar 01 04:00:00 EST 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576151· OSTI ID:6914929

Rasey, J S; Nelson, N J; Mahler, P; Anderson, K; Krohn, K A; Menard, T

The ability of WR-2721 to protect mice against two modes of death following whole-body radiation with /sup 137/Cs ..gamma.. rays or d(22)+Be neutrons was examined. For single fraction, 400 mg/kg WR-2721 was administered prior to irradiation. In two-fraction exposure, the dose was 275 mg/kg given prior to each fraction. Dose modification factors (DMFs) were calculated as ratios of LD/sub 50/7/ values. For single fractions of ..gamma.. rays, the DMF was 1.74 for the LD/sub 50/7/ end point and for LD/sub 50/30/, the DMF for single fractions was 2.25. For two fractions 3 hr apart, it was 1.88. For single fractions of cyclotron neutrons, the DMF was 1.32 for LD/sub 50/7/. Measured with the LD/sub 50/30/ end point, the DMF for single neutron doses was 1.41 and for two fractions, 1.19. Substantial radioprotection of bone marrow and intestinal epithelium against cyclotron neutrons was seen in these investigations. Biodistribution studies were done following ip injection of /sup 35/S-labeled WR-2721 into C3H mice bearing RIF-1 tumors. High levels of /sup 35/S were achieved and retention times were long in certain normal tissues which respond at early or late times postradiation and may be dose limiting in radiotherapy: kidney, liver, savary gland, and lung. These combined observations suggest that there is potential for protecting dose-limiting, late-responding normal tissue in the radiotherapy of human cancer with both neutrons and conventional radiotherapy.

• Research Organization: Univ. of Washington, Seattle
• OSTI ID: 6914929
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 97:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CESIUM 137
CESIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DOSES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EVEN-ODD NUCLEI
EXTERNAL IRRADIATION
FAST NEUTRONS
FERMIONS
FRACTIONATED IRRADIATION
GAMMA RADIATION
GLANDS
HADRONS
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
KIDNEYS
LETHAL DOSES
LETHAL RADIATION DOSE
LIGHT NUCLEI
LIVER
LUNGS
MAMMALS
MICE
NEUTRONS
NUCLEI
NUCLEONS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION DOSES
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RESPIRATORY SYSTEM
RODENTS
SALIVARY GLANDS
SULFUR 35
SULFUR ISOTOPES
THIOLS
TISSUE DISTRIBUTION
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES