Alpha slow-moving high-density-lipoprotein subfraction in serum of a patient with radiation enteritis and peritoneal carcinosis

Journal Article · Fri Mar 31 23:00:00 EST 1989 · Clin. Chem. (Winston-Salem, N.C.); (United States)

OSTI ID:6097304

Peynet, J; Legrand, A; Messing, B; Thuillier, F; Rousselet, F

An alpha slow-moving high-density-lipoprotein (HDL) subfraction was seen in a patient presenting with radiation enteritis and peritoneal carcinosis, who was given long-term cyclic parenteral nutrition. This subfraction, observed in addition to normal HDL, was precipitated with low-density lipoproteins (LDL) and very-low-density lipoproteins (VLDL) by sodium phosphotungstate-magnesium chloride. The patient's serum lipoproteins were analyzed after fractionation by density gradient ultracentrifugation. The alpha slow-moving HDL floated in the ultracentrifugation subfractions with densities ranging from 1.028 to 1.084 kg/L, and their main apolipoproteins included apolipoprotein E in addition to apolipoprotein A-I. These HDL were larger than HDL2. The pathogenesis of this unusual HDL subfraction is hypothesized.

• Research Organization: Laboratoire Central de Biochimie, Paris (France)
• OSTI ID: 6097304
• Journal Information: Clin. Chem. (Winston-Salem, N.C.); (United States), Journal Name: Clin. Chem. (Winston-Salem, N.C.); (United States) Vol. 35:4; ISSN CLCHA
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
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RADIATION EFFECTS
RADIATION INJURIES
RADIOINDUCTION
SEPARATION PROCESSES
SEROUS MEMBRANES
STEROIDS
STEROLS
SYNTHESIS
ULTRACENTRIFUGATION