Metabolic interrelationships and adaptations in selenium toxicity
The experiments discussed in this review show that the toxicity of selenium can be decreased in a number of different ways; arsenic diminishes selenium poisoning by stimulating the excretion of Se into the bile; linseed oil meal apparently lessens the effects of chronic selenosis by binding the Se in the tissues in a less toxic form; and methionine when fed in conjunction with vitamin E helps prevent liver damage due to Se, perhaps by increasing the urinary or pulmonary excretion of the element. D-Penicillamine or dithiothreitol had little beneficial value against selenium intoxication under our conditions. There is growing evidence that certain living systems can undergo an adaptive response to exposure to high levels of selenium. 43 references, 11 tables.
- Research Organization:
- Dept. of Agriculture, Beltsville, MD
- OSTI ID:
- 6096789
- Journal Information:
- Ann. N.Y. Acad. Sci.; (United States), Journal Name: Ann. N.Y. Acad. Sci.; (United States) Vol. 192; ISSN ANYAA
- Country of Publication:
- United States
- Language:
- English
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560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
DATA
DRUGS
ELEMENTS
EXPERIMENTAL DATA
INFORMATION
INHIBITION
LIPOTROPIC FACTORS
METHIONINE
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
SELENIUM
SEMIMETALS
TOLERANCE
TOXICITY
VITAMIN E
VITAMINS