Behavior of (/sup 185/W)thiotungstates injected into sheep and the influence of copper: their fate and the effect of the compounds upon plasma copper

Journal Article · Wed Feb 01 04:00:00 EST 1989 · J. Inorg. Biochem.; (United States)

DOI:https://doi.org/10.1016/0162-0134(89)80004-2· OSTI ID:6096207

Mason, J; Mulryan, G; Lamand, M; LaFarge, C

(185W)trithio- and tetrathiotungstates (0.5 mg W) were injected intravenously into sheep. The compounds circulated in plasma bound reversibly to plasma proteins, particularly to albumin. After the first few minutes, levels declined exponentially with a T 1/2 of 12-14 hr. The initial movement of (185W)trithiotungstate from the plasma compartment was delayed transiently by the immediate injection of copper (2-6 mg); the longer-term metabolism was unaffected. The final fate of the compounds appeared to be hydrolysis and excretion in urine as (185W)tungstate. 185W from (185W)trithiotungstate appeared more rapidly than from (185W)tetrathiotungstate, but in both the rate was unaffected by copper injections. Since the appearance in urine did not correspond to the disappearance from plasma, it was suggested that the hydrolysis occurred in extravascular tissues and that the liver might be the site. A control experiment showed that (185W)tungstate in plasma was very rapidly cleared (and appeared in urine). At higher W levels (25-50 mg W per sheep per day), systematic copper metabolism was perturbed since plasma copper levels rose. The experiments demonstrated that in sheep the behavior and the effects of thiotungstates and thiomolybdates are sufficiently similar for 185W to be used as a more convenient alternative to 99Mo for longer-term studies on the interaction of the compounds with copper metabolism in animals.

• Research Organization: Dublin Univ. (Ireland)
• OSTI ID: 6096207
• Journal Information: J. Inorg. Biochem.; (United States), Journal Name: J. Inorg. Biochem.; (United States) Vol. 35:2; ISSN JIBID
• Country of Publication: United States
• Language: English

Related Subjects

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560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
COPPER
DAYS LIVING RADIOISOTOPES
DOMESTIC ANIMALS
ELEMENTS
EVEN-ODD NUCLEI
HEAVY NUCLEI
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METABOLISM
METALS
MINUTES LIVING RADIOISOTOPES
MOLYBDENUM 99
MOLYBDENUM ISOTOPES
NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPES
RUMINANTS
SHEEP
TRACER TECHNIQUES
TRANSITION ELEMENTS
TUNGSTEN
TUNGSTEN 185
TUNGSTEN ISOTOPES
VERTEBRATES