Effects of soil on percutaneous absorption of toluene in male rats
Journal Article
·
· J. Toxicol. Environ. Health; (United States)
Previous assessments of health risks from soil-adsorbed chemical exposures relied on extrapolations from data derived with pure compounds. However, interactions between chemical and soil can alter the rate, amount, and form of chemical that enters the body, resulting in effects that are different from those that occur after exposures to chemical alone. In this study, male rats were treated dermally with (/sup 14/C)toluene alone or adsorbed to either a sandy or a clay soil. Both soils produced a higher plasma concentration compared to pure toluene, with a statistical decrease in half-life of absorption observed after sandy soil-adsorbed treatment. The time to reach peak plasma concentration, half-life of elimination, and area under the plasma concentration-time curve (AUC) were similar for all groups. Skin and fat contained the highest concentration of radioactivity 48 h after all treatments. Pure and soil-adsorbed toluene were primarily metabolized and excreted via the kidney rather than exhaled. Furthermore, soil treatment did not alter the percentages of the metabolic products.
- Research Organization:
- Univ. of Medicine and Dentistry of New Jersey, Newark (USA)
- OSTI ID:
- 6096090
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 26:3; ISSN JTEHD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ADIPOSE TISSUE
ADSORPTION
ALKYLATED AROMATICS
ANIMAL TISSUES
ANIMALS
AROMATICS
BIOLOGICAL AVAILABILITY
BIOLOGICAL HALF-LIFE
BIOLOGICAL MODELS
BODY
CARBON 14 COMPOUNDS
CONNECTIVE TISSUE
HYDROCARBONS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
ORGANIC COMPOUNDS
RATS
RODENTS
SKIN ABSORPTION
SOILS
SORPTION
SORPTIVE PROPERTIES
SURFACE PROPERTIES
TISSUES
TOLUENE
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ADIPOSE TISSUE
ADSORPTION
ALKYLATED AROMATICS
ANIMAL TISSUES
ANIMALS
AROMATICS
BIOLOGICAL AVAILABILITY
BIOLOGICAL HALF-LIFE
BIOLOGICAL MODELS
BODY
CARBON 14 COMPOUNDS
CONNECTIVE TISSUE
HYDROCARBONS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
ORGANIC COMPOUNDS
RATS
RODENTS
SKIN ABSORPTION
SOILS
SORPTION
SORPTIVE PROPERTIES
SURFACE PROPERTIES
TISSUES
TOLUENE
TRACER TECHNIQUES
UPTAKE
VERTEBRATES