Sex differences in the bioavailability of soil-absorbed naphthalene in dermally exposed rats

Conference · Mon Feb 26 04:00:00 EST 1990 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5678335

Skowronski, G; Kadry, A; Turkall, R; Botrous, M; Abdel-Rahman, M S ^[1]

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1. New Jersey Medical School, Newark (United States)

Naphthalene is a major coal tar component found in hazardous waste disposal sites. The purpose of this study was to assess the bioavailability of clay (C) or sandy (S) soil-adsorbed {sup 14}C-naphthalene versus chemical alone (P) following dermal treatment of male and female rats. In males, C significantly increased the amount of radio-activity absorbed into plasma and excreted in urine while S lowered the peak plasma concentration and reduced expired air excretion compared to P. However, in females neither soil significantly altered the area under the plasma concentration time curve (AUC). Furthermore, C significantly increased the quantity of radio-activity excreted in expired air. Forty-eight hours after dosing, skin and ileum contained the highest tissue concentration of radioactivity in all groups of both sexes. The predominant urinary metabolites were 2.7- and 1.2-dihydroxynaptha-, lene, respectively, in all male and female groups.

• OSTI ID: 5678335
• Report Number(s): CONF-9004153--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 4:3
• Country of Publication: United States
• Language: English

Related Subjects

551001 -- Physiological Systems-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
AROMATICS
BIOLOGICAL AVAILABILITY
CONDENSED AROMATICS
HYDROCARBONS
MAMMALS
NAPHTHALENE
ORGANIC COMPOUNDS
RATS
RODENTS
SEX DEPENDENCE
SKIN ABSORPTION
SOILS
UPTAKE
VERTEBRATES