Evaluation of the SOS chromotest for the detection of antimutagens

Journal Article · Mon Dec 31 23:00:00 EST 1990 · Environmental and Molecular Mutagenesis; (United States)

DOI:https://doi.org/10.1002/em.2850170407· OSTI ID:6092979

Sato, Takahiko; Chikazawa, Kazuhiko; Yamamori, Hidetomo; Ose, Youki; Nagase, Hisamitsu; Kito, Hideaki ^[1]

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1. Gifu Pharmaceutical Univ. (Japan)

The SOS chromotest was applied for the detection of antimutagens. To raise SOS induction, the bacteria were treated with the mutagens, UV, 4-nitroquinoline N-oxide (4NQO), N-methyl-N{prime}-nitro-N-nitroso-guanidine (MNNG), or benzo(a)pyrene (B(a)p). The inhibitory effects of {sub L}-ascorbic acid, glutathione, vanillin,5-fluorouracil (5-FU), 5-chlorouracil (5-CU), cobaltous chloride, sodium selenite and sodium arsenite, which are known as antimutagens, were investigated with their addition either simultaneously or post treatment time. In became clear that the SOS chromotest was very useful for the detection of antimutagens.

• OSTI ID: 6092979
• Journal Information: Environmental and Molecular Mutagenesis; (United States), Journal Name: Environmental and Molecular Mutagenesis; (United States) Vol. 17:4; ISSN 0893-6692; ISSN EMMUE
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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ESCHERICHIA COLI
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O-GLYCOSYL HYDROLASES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN COMPOUNDS
PEPTIDES
PHOSPHATASES
POLYPEPTIDES
PROTEINS
PYRIDINES
PYRIMIDINES
QUINOLINES
RADIATION EFFECTS
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RADIOINDUCTION
RADIOPROTECTIVE SUBSTANCES
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