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Radiolabeled anti platelet monoclonal antibody for imaging in-vivo thrombi

Patent ·
OSTI ID:6081939
; ;
A radiolabeled monoclonal antibody radiolabeled with a halogen or metallic radionuclide selected from the group consisting of [sup 123]I, [sup 125]I, [sup 131]I, [sup 111]In-DTPA, [sup 99]mTc and [sup 97]Ru, wherein the monoclonal antibody is of the class IgG, produced by a hybridoma formed by fusion of cells from a BALB/C mouse myeloma line, X63.Ag8.653 and spleen cells from a BALB/c mouse previously immunized with human blood platelets, which antibody: (a) reacts readily with normal human platelets and with dog platelets; (b) fails to react with thrombasthenic human platelets or human platelets whose GPIIb/IIIa complex is dissociated with EDTA and (c) reacts slowly with inactivated platelets and substantially twice as rapidly with ADP activated platelets; and (d) completely blocks the interaction of fibrinogen with platelets induced by ADP.
Assignee:
Research Foundation of State Univ. of New York, Albany, NY (United States)
Patent Number(s):
US 5225181; A
Application Number:
PPN: US 7-826650
OSTI ID:
6081939
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADP
AMINO ACIDS
ANIMAL CELLS
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CHELATING AGENTS
CHEMICAL PREPARATION
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC USES
DISEASES
DOGS
DRUGS
DTPA
EDTA
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE 123
IODINE 125
IODINE 131
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MAMMALS
MAN
MATERIALS
MICE
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NUCLEI
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PRIMATES
RADIOISOTOPES
RADIOPHARMACEUTICALS
RADIOPROTECTIVE SUBSTANCES
RODENTS
RUTHENIUM 97
RUTHENIUM ISOTOPES
SOMATIC CELLS
SPLEEN CELLS
SYNTHESIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
THROMBOSIS
TUMOR CELLS
USES
VASCULAR DISEASES
VERTEBRATES
YEARS LIVING RADIOI