Effect of a selective thromboxane synthase inhibitor on arterial graft patency and platelet deposition in dogs

Journal Article · Sat Aug 01 04:00:00 EDT 1987 · Arch. Surg. (Chicago); (United States)

DOI:https://doi.org/10.1001/archsurg.1987.01400200037005· OSTI ID:6080313

McDaniel, M D; Huntsman, W T; Miett, T O; Cronenwett, J L

This study examined the effect of selective thromboxane synthase inhibition and nonselective cyclooxygenase inhibition on vascular graft patency and indium 111-labeled platelet deposition in 35 mongrel dogs undergoing carotid artery replacement with 4 mm X 4 cm polytetrafluoroethylene (PTFE) (one side) and Dacron (opposite side) end-to-end grafts. Aspirin-dipyridamole therapy improved one-week graft patency, from 46% in untreated dogs to 93% in treated dogs. Thromboxane synthase inhibition (U-63557A) improved graft patency in these dogs to 81%. Both drug treatments reduced platelet deposition on Dacron and PTFE grafts by 48% to 68% compared with control dogs. Dacron grafts accumulated significantly more platelets than PTFE grafts but had comparable patency rates. Low-dose aspirin therapy had no significant effect on either graft patency or platelet deposition. All treatment groups showed a 60% to 76% reduction in serum thromboxane B2, but only thromboxane synthase inhibitor treatment increased plasma 6-keto-prostaglandin F1 alpha by 100%. Selective thromboxane synthase inhibition improved small-caliber prosthetic graft patency to the same extent as did conventional cyclooxygenase inhibition in this preliminary study.

• Research Organization: Dartmouth-Hitchcock Medical Center, Hanover, NH
• OSTI ID: 6080313
• Journal Information: Arch. Surg. (Chicago); (United States), Journal Name: Arch. Surg. (Chicago); (United States) Vol. 122:8; ISSN ARSUA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
550600 -- Medicine
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION
BLOOD PLATELETS
BLOOD VESSELS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CAROTID ARTERIES
DAYS LIVING RADIOISOTOPES
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENZYME INHIBITORS
FLUORINATED ALIPHATIC HYDROCARBONS
GRAFT-HOST REACTION
GRAFTS
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROXY ACIDS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
MEDICAL SUPPLIES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC POLYMERS
ORGANS
POLYETHYLENES
POLYMERS
POLYOLEFINS
POLYTETRAFLUOROETHYLENE
PROSTHESES
RADIOISOTOPES
SALICYLIC ACID
TRACER TECHNIQUES
TRANSPLANTS
VASODILATORS
VERTEBRATES