Final report on the developmental toxicity of methacrylonitrile (CAS No. 126-98-7) in Sprague-Dawley (CS[trademark]) rats. Report for March-June 1992

Technical Report · Thu Apr 01 00:00:00 EST 1993

OSTI ID:6078356

The study was conducted to assess the potential for orally administered methacrylonitrile (MILE) to cause developmental toxicity. Human exposure to MILE occurs in industrial settings, as a component of mainstream cigarette smoke from unfiltered cigarettes, and possibly as a result of ingestion of beverages bottled in plastic containers. MILE (CAS No. 126-98-7) was administered by gavage in water to mated CD rats (26/group) on gestation days (GD) 6 through 15 at levels of 0, 5, 25 or 50 mg/kg/day. Animals were observed daily for clinical signs of toxicity. Body weight was recorded on the mornings of gd 0, 3, 6 through 15, 18 and 20. Mean food and water consumption was recorded for the animals in each group on GD 0, 3, 6, 9, 12, 15, 18, and 20. All animals in the developmental toxicity study were killed on GD 20 and examined for maternal body and organ weights, implant status, fetal weight, sex, and morphological development.

• Research Organization: Research Triangle Inst., Research Triangle Park, NC (United States). Center for Life Sciences and Toxicology
• OSTI ID: 6078356
• Report Number(s): PB-93-190072/XAB; CNN: NIEHS-N01-ES-95255
• Resource Relation: Other Information: See also PB--93-190080
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NITRILES
TOXICITY
ANIMALS
BEVERAGES
BODY
CONSUMPTION RATES
CONTAINERS
DEATH
DOSE-RESPONSE RELATIONSHIPS
ENVIRONMENTAL EXPOSURE
FOOD
INDUSTRY
INGESTION
PHYSIOLOGY
RATS
RESEARCH PROGRAMS
SEX
SEX DEPENDENCE
SMOKES
TOLERANCE
WATER REQUIREMENTS
WEIGHT
AEROSOLS
COLLOIDS
DEMAND
DISPERSIONS
INTAKE
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RESIDUES
RODENTS
SOLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology