Induction of urinary bladder hyperplasia in Sprague-Dawley rats orally administered tri-n-butyl phosphate

Journal Article · · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1985.10545937· OSTI ID:6037571

Laham, S; Long, G; Broxup, B

The effects of tri-n-butyl phosphate (TBP) were investigated in the Sprague-Dawley rat over an 18-wk period. Groups of randomized female (average weight (AW) = 206 +/- 10 g) and male (AW = 294 +/- 13 g) rats were divided into low-dose, high-dose, and control groups (12 rats/sex x group). Tri-n-butyl phosphate was administered by gavage once a day for 5 days/wk over an 18-wk period. Low-dose animals received 0.20 g/kg x day throughout the experiment and high-dose animals received 0.30 g/kg x day for the first 6 wk. For the remaining 12 wk, the high-dose level was increased to 0.35 g/kg x day. Histopathological examination of tissues revealed that all test rats examined developed diffuse hyperplasia of the urinary bladder epithelium. Similar changes were not found in the control animals.

• Research Organization: Health and Welfare Canada, Ottawa, Ontario
• OSTI ID: 6037571
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 40:6; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BLADDER
BODY
BUTYL PHOSPHATES
DATA
ESTERS
EXPERIMENTAL DATA
INFORMATION
MAMMALS
NUMERICAL DATA
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PHOSPHORIC ACID ESTERS
RATS
RODENTS
TBP
TOXICITY
URINARY TRACT
VERTEBRATES