High density lipoprotein (HDL) metabolism in noninsulin-dependent diabetes mellitus: measurement of HDL turnover using tritiated HDL

Journal Article · Tue Sep 01 00:00:00 EDT 1987 · J. Clin. Endocrinol. Metab.; (United States)

DOI:https://doi.org/10.1210/jcem-65-3-512· OSTI ID:6071926

Golay, A; Zech, L; Shi, M Z; Chiou, Y A; Reaven, G M; Chen, Y D

High density lipoprotein (HDL) kinetics were studied by injecting (/sup 3/H)apoprotein A-I (apoA-I)/HDL into 12 subjects with normal glucose tolerance and 12 patients with noninsulin-dependent diabetes mellitus (NIDDM). The results indicate that the mean fractional catabolic rate (FCR) of apoA-I/HDL was significantly faster (0.63 +/- 0.07 (+/- SEM) vs. 0.39 +/- 0.02 1/day; P less than 0.001) and the apoA-I/HDL synthetic rate greater (29.4 +/- 2.9 vs. 22.9 +/- 1.3 mg/kg X day; P less than 0.02) in patients with NIDDM than in normal subjects. Furthermore, there were statistically significant inverse relationships between apoA-I/HDL FCR and plasma levels of both HDL cholesterol (r = -0.71; P less than 0.001) and apoA-I (r = -0.63; P less than 0.001). In addition, the increase in apoA-I/HDL FCR was directly related to fasting plasma glucose (r = 0.78; P less than 0.001) and insulin (r = 0.76; P less than 0.001) concentrations. These data support the view that the decrease in plasma HDL cholesterol and apoA-I levels commonly found in patients with noninsulin-dependent diabetes is due to an increase in the catabolic rate of apoA-I/HDL secondary to the defects in carbohydrate metabolism present in these patients.

• Research Organization: Stanford Univ. School of Medicine, CA
• OSTI ID: 6071926
• Journal Information: J. Clin. Endocrinol. Metab.; (United States), Vol. 65:3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
LIPOPROTEINS
METABOLISM
CHOLESTEROL
DIABETES MELLITUS
GLUCOSE
INSULIN
PATIENTS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ALDEHYDES
CARBOHYDRATES
DISEASES
ENDOCRINE DISEASES
HEXOSES
HORMONES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIPIDS
METABOLIC DISEASES
MONOSACCHARIDES
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PROTEINS
SACCHARIDES
STEROIDS
STEROLS
550501* - Metabolism- Tracer Techniques
550901 - Pathology- Tracer Techniques