Increased chromium and nickel content in lung tissue and bronchial carcinoma
In 25 random autopsies, chromium (Cr) and nickel (Ni) in lung tissue and regional lymph nodes were analysed by means of flameless atomic absorption spectrometry (AAS). The subjects originate from Bochum in the Ruhr District, which is defined as a particular pollution area with locally high Cr and Ni emissions. The subjects examined from Bochum (BO) and vicinity have Cr and Ni concentrations about 5 and 6 times higher than those in a previous series form Muenster (MS) and vicinity (outside the particular pollution area), which is used for comparison purposes. BO and MS data showed an age-dependent increase of chromium and nickel in the lung, and in both data sets as well as in the combined, the Cr and Ni values showed extremely high correlations. The Cr and Ni concentrations (BO) in lung (3.47 +/- 2.53 micrograms Cr/g, 1.09 +/- 1.43 micrograms Ni/g dry weight) and lymph node tissue (6.30 +/- 3.72 micrograms Cr/g, 1.00 +/- 0.58 micrograms Ni/g dry weight) do not show any correlation. The BO data contained four cases of bronchial carcinoma (all male), three of which showed pulmonary Cr and Ni concentrations that lie clearly above the predicted level. One case of bronchial carcinoma had extremely high Cr and Ni values; an occupational exposure as dental laboratory technician is taken into consideration.
- Research Organization:
- Bundesanstalt fuer Arbeitsschutz, Dortmund, Germany, F.R.
- OSTI ID:
- 6068368
- Journal Information:
- Am. J. Ind. Med.; (United States), Vol. 11:6
- Country of Publication:
- United States
- Language:
- English
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CHROMIUM
BIOLOGICAL ACCUMULATION
HEALTH HAZARDS
NICKEL
ABSORPTION SPECTROSCOPY
AGE DEPENDENCE
AIR POLLUTION
AUTOPSY
CARCINOGENESIS
CORRELATIONS
DATA ANALYSIS
ENVIRONMENTAL EXPOSURE
FEDERAL REPUBLIC OF GERMANY
INDUSTRIAL WASTES
LUNGS
LYMPH NODES
OCCUPATIONAL EXPOSURE
STATISTICAL DATA
BODY
DATA
DIAGNOSTIC TECHNIQUES
ELEMENTS
EUROPE
HAZARDS
INFORMATION
LYMPHATIC SYSTEM
METALS
NUMERICAL DATA
ORGANS
PATHOGENESIS
POLLUTION
RESPIRATORY SYSTEM
SPECTROSCOPY
TRANSITION ELEMENTS
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WESTERN EUROPE
560300* - Chemicals Metabolism & Toxicology