Development of a comparative potency method for cancer risk assessment of complex mixtures using short-term in vivo and in vitro bioassays
Journal Article
·
· Toxicol. Ind. Health; (United States)
A comparative potency method for cancer risk assessment has been developed based on a constant relative potency hypothesis. This method was developed and tested using data from a battery of short-term mutagenesis bioassays, animal tumorigenicity data and human lung cancer risk estimations. This data base was developed for a series of complex mixtures including emissions from coke ovens, roofing tar pots, cigarette smoke and automotive engines. The series of automobiles used in this study included both diesel- and gasoline-powered vehicles. The assumptions inherent in this method are discussed, together with the methods and data base used to test these assumptions.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC
- OSTI ID:
- 6068227
- Journal Information:
- Toxicol. Ind. Health; (United States), Journal Name: Toxicol. Ind. Health; (United States) Vol. 1:4; ISSN TIHEE
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
AUTOMOBILES
BIOASSAY
BODY
CARCINOGENESIS
COLLOIDS
COMPARATIVE EVALUATIONS
DIESEL ENGINES
DISEASES
DISPERSIONS
ENERGY SOURCES
ENGINES
FOSSIL FUELS
FUELS
GASEOUS WASTES
HEAT ENGINES
IN VITRO
IN VIVO
INTERNAL COMBUSTION ENGINES
LABORATORY ANIMALS
LUNGS
MAMMALS
MAN
MIXTURES
MUTAGENS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOGENESIS
PETROLEUM
POLLUTANTS
PRIMATES
RESIDUES
RESPIRATORY SYSTEM
RISK ASSESSMENT
SMOKES
SOLS
SPARK IGNITION ENGINES
TAR
TOBACCO SMOKES
VEHICLES
VERTEBRATES
WASTES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
AUTOMOBILES
BIOASSAY
BODY
CARCINOGENESIS
COLLOIDS
COMPARATIVE EVALUATIONS
DIESEL ENGINES
DISEASES
DISPERSIONS
ENERGY SOURCES
ENGINES
FOSSIL FUELS
FUELS
GASEOUS WASTES
HEAT ENGINES
IN VITRO
IN VIVO
INTERNAL COMBUSTION ENGINES
LABORATORY ANIMALS
LUNGS
MAMMALS
MAN
MIXTURES
MUTAGENS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOGENESIS
PETROLEUM
POLLUTANTS
PRIMATES
RESIDUES
RESPIRATORY SYSTEM
RISK ASSESSMENT
SMOKES
SOLS
SPARK IGNITION ENGINES
TAR
TOBACCO SMOKES
VEHICLES
VERTEBRATES
WASTES