Denitrosation of N-nitrosodimethylamine and N-nitrosomethylurea by liver microsomes from trout (Salmo gairdneri Rich. )
Journal Article
·
· Environ. Res.; (United States)
OSTI ID:6065135
N-Nitrosodimethylamine and N-nitrosomethylurea are partially metabolized to nitrite and formaldehyde by trout liver microsomes. Results show that the denitrosation pathway of both N-nitroso derivatives is NADPH-dependent, requires molecular oxygen, and is inhibited by common inhibitors of microsomal enzyme activities.
- Research Organization:
- Universita di Genova, Italy
- OSTI ID:
- 6065135
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 42:2; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Microsomal metabolism of NDMA and analogs
Oxidation of N-methylthiobenzamide and N-methylthiobenzamide S-oxide by liver and lung microsomes
Metabolism of polycyclic hydrocarbons by a highly active aryl hydrocarbon hydroxylase system in the liver of a trout species
Conference
·
Fri May 01 00:00:00 EDT 1987
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:6119929
Oxidation of N-methylthiobenzamide and N-methylthiobenzamide S-oxide by liver and lung microsomes
Journal Article
·
Wed May 01 00:00:00 EDT 1985
· Toxicol. Appl. Pharmacol.; (United States)
·
OSTI ID:6177758
Metabolism of polycyclic hydrocarbons by a highly active aryl hydrocarbon hydroxylase system in the liver of a trout species
Journal Article
·
Mon Apr 07 00:00:00 EDT 1975
· Biochem. Biophys. Res. Commun.; (United States)
·
OSTI ID:7187402
Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
AQUATIC ORGANISMS
BIOLOGICAL FUNCTIONS
BIOLOGICAL PATHWAYS
BODY
CELL CONSTITUENTS
COENZYMES
CONTAMINATION
DIGESTIVE SYSTEM
ENZYME ACTIVITY
FISHES
FORMALDEHYDE
FUNCTIONS
GLANDS
LIVER
METABOLISM
MICROSOMES
NADP
NITRITES
NITROGEN COMPOUNDS
NITROSO COMPOUNDS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOIDS
ORGANS
OXYGEN COMPOUNDS
TROUT
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
AQUATIC ORGANISMS
BIOLOGICAL FUNCTIONS
BIOLOGICAL PATHWAYS
BODY
CELL CONSTITUENTS
COENZYMES
CONTAMINATION
DIGESTIVE SYSTEM
ENZYME ACTIVITY
FISHES
FORMALDEHYDE
FUNCTIONS
GLANDS
LIVER
METABOLISM
MICROSOMES
NADP
NITRITES
NITROGEN COMPOUNDS
NITROSO COMPOUNDS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOIDS
ORGANS
OXYGEN COMPOUNDS
TROUT
VERTEBRATES