Metabolism of polycyclic hydrocarbons by a highly active aryl hydrocarbon hydroxylase system in the liver of a trout species

Journal Article · Mon Apr 07 00:00:00 EDT 1975 · Biochem. Biophys. Res. Commun.; (United States)

DOI:https://doi.org/10.1016/S0006-291X(75)80431-1· OSTI ID:7187402

Ahokas, J T; Pelkonen, O; Karki, N T

In sharp contrast to earlier beliefs, some fish (trout) liver-microsomes are highly capable of metabolizing benzo(..cap alpha..)pyrene. The hydroxylating system is a typical monooxygenase system in many respects when compared with the mammalian system, needing oxygen and NADPH for full activity. The trout liver-microsomes convert benzo(..cap alpha..)pyrene to dihydrodiols and hydroxymetabolites at a rate 5 to 10 times higher than the male rat liver-microsomes, when measured per mg of microsomal protein. The trout liver-microsomes metabolize benzo(..cap alpha..)pyrene 15 to 30 times as fast as the male rat liver-microsomes if the activity is measured per unit of cytochrome P-450 and NADPH-cytochrome c reductase.

• Research Organization: Univ. of Oulu, Finland
• OSTI ID: 7187402
• Journal Information: Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 63:3; ISSN BBRCA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BENZOPYRENE
BODY
CELL CONSTITUENTS
CONDENSED AROMATICS
DIGESTIVE SYSTEM
ENZYMES
FISHES
GLANDS
HYDROCARBONS
HYDROXYLASE
LIVER
MAMMALS
METABOLISM
MICROSOMES
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
OXIDOREDUCTASES
RATS
RODENTS
TROUT
VERTEBRATES