Interactions of cryptosin with mammalian cardiac beta-adrenoceptors

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Drug and Chemical Toxicology; (USA)

DOI:https://doi.org/10.3109/01480549009018119· OSTI ID:6062616

Rao, V R; Banning, J W ^[1]

---

1. Wayne State Univ., Detroit, MI (USA)

Cryptosin - a new cardenolide from the leaves of Cryptolepis buchanani R S was found to be a potent positive inotropic agent. In experiments with dog heart ex vivo, the rise in the cardiac rate associated with an increase in dP/dtmax and left ventricular pressure (LVP) correlated with changes in the beta-adrenoceptor densities as measured by the binding of 3H-Dihydroalprenolol (DHA). A significant change in the beta-adrenoceptor densities was observed when cryptosin was incubated with guinea pig and dog heart sarcolemmal membranes in vitro. Analysis of the binding of 3H-DHA in post-cryptosin treated membranes indicated a non-specific type of interaction of cryptosin with mammalian cardiac beta-adrenoceptors.

• OSTI ID: 6062616
• Journal Information: Drug and Chemical Toxicology; (USA), Journal Name: Drug and Chemical Toxicology; (USA) Vol. 13:2-3; ISSN 0148-0545; ISSN DCTOD
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
BODY
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CELL MEMBRANES
DOGS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
GLYCOSIDES
GUINEA PIGS
HEART
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
ORGANIC COMPOUNDS
ORGANS
PROTEINS
REACTION KINETICS
RECEPTORS
RODENTS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES